Diabetes in Mice Rapidly Cured in Experiment on Human Stem Cells

Diabetes in Mice Rapidly Cured Human Stem Cells

In a study conducted at Washington University School of Medicine, the researchers have figured out a new way to coax human pluripotent stem cells (hPSCs) into pancreatic beta cells that make insulin. During the study, when these insulin-producing cells were transplanted into mice with severe diabetes, it was rapidly cured.

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These mice had very severe diabetes with blood sugar readings of more than 500 milligrams per decilitre of blood – levels that could be fatal for a person. When we gave the mice the insulin-secreting cells, within two weeks their blood glucose levels had returned to normal and stayed that way for many months

Jeffrey R. Millman, Biomedical Engineer at Washington University

The work published on 24 February in the journal Nature Biotechnology, holds huge promise for future diabetic treatments if it can be successfully replicated in humans.

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